Читать книгу Clinical Dilemmas in Diabetes - Группа авторов - Страница 55

 Type 2 diabetes is differentiated from type 1 diabetes by what it is not i.e. a lack of evidence of immune‐mediated destruction of insulin‐secreting cells. This oversimplification may miss some of the heterogeneity present in type 2 diabetes.

 Current methods of differentiating type 1 from type 2 diabetes have significant limitations and lack sensitivity and specificity.

 Glucose‐ and lipo‐toxicity can adversely affect insulin secretion in the short term although this state of affairs is not necessarily permanent.

 Attention to a possible diagnosis of monogenic diabetes and achieving glycemic control safely and effectively are more likely to be clinically relevant than current attempts to sub‐classify type 2 diabetes.