Читать книгу Genetic Analysis of Complex Disease - Группа авторов - Страница 29

It may seem self‐evident that a careful study design is necessary for a successful study. However, it is not enough to decide on a general design of “collect cases and controls, genotype on a genome‐wide chip, do GWAS analysis.” Each step in the study requires substantial thought, and the decisions made at one step will have implications for each of the others. Much as a team of engineers and architects must project unintended side effects from a change in a structural design, lest a catastrophic failure ensue, researchers must consider carefully all aspects of the experimental design lest they doom themselves to making inappropriate conclusions based on inadequately obtained and interpreted results.