Читать книгу Genetic Analysis of Complex Disease - Группа авторов - Страница 72

One of the characteristics of a genetic disorder is that it aggregates, or clusters, within families. If familial clustering of a disorder is observed, there are several approaches described below to determine if this observation is statistically significant. However, keep in mind that familial clustering may also be due to a common familial environment or simply due to chance. So, while statistical evidence of familial clustering may support the involvement of genetics in the disorder under investigation, it will be necessary to identify the underlying genes to confirm this.