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Aetiopathogenesis

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 The mother's age (>35 years) is considered a risk factor

 In 95% of cases, the syndrome is due to the presence of an additional copy of chromosome 21 in all cells (‘trisomy 21’)Figure 2.3.5 Orthodontic therapy can be successfully performed in selected patients.

 In 5% of the remaining cases, the syndrome expresses a translocation or mosaicism

A Practical Approach to Special Care in Dentistry

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