Читать книгу Mutagenic Impurities - Группа авторов - Страница 98

This section has five Q&As that start with a direct continuation to Q&A 6.4, which relates to Ames positive impurities. Then an interesting question is presented regarding the application of the LTL to AIs derived by linear extrapolation from TD₅₀ values but not to PDEs derived for impurities. Then a Q&A relates to the explanations and implications of moving HIV disease from treatment duration of <10 years to lifetime treatment, and finally a Q&A relates to the application of limits for individual impurities when three or more Class 2 and Class 3 impurities are present.