Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 472

Primary sclerosing cholangitis is a rare disorder, more often seen in males, with a prevalence rate of about 1 in 10,000. It is characterized by hepatic ductal stricturing, which leads to progressive jaundice and cirrhosis.³⁰ It is often associated with inflammatory bowel disease, usually ulcerative colitis. It usually presents before age 40, but if it presents after 50 is less likely to be associated with inflammatory bile disease. It is best diagnosed by MRI cholangiogram or endoscopic cholangiogram, and there is no effective treatment. In jaundice of unclear aetiology, the bile ducts must be visualized to look for primary sclerosing cholangitis or other causes of bile duct obstruction like pancreatic carcinoma or common bile duct stones.