Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 50

 There is experimental evidence of the contribution of several molecular and cellular pathways to ageing.

 These hallmarks of biological ageing include genomic instability, epigenetic changes, mitochondrial dysfunction, loss of proteostasis, metabolic dysfunction, cell senescence, stem cell exhaustion, and inflammation.

 Some of these pathways can be modulated by lifestyle interventions and drugs.

 According to the geroscience hypothesis, accumulation of diseases and loss of functions with ageing are driven by common biological mechanisms, and measures of biological ageing may predict adverse outcomes in late life and ultimately identify interventions that extend healthspan.

 Conceptual confusion is one of the obstacles to significant advances in biogerontology and geroscience: it entails difficulties in measuring the rate of ageing, defining the level of ageing, assessing when ageing starts, and so on.

 The evolutionary theory of ageing is robust but should be made more precise in light of the results of the molecular biology of ageing.