Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 532

The underlying pathophysiological mechanism in acute pancreatitis varies based on the inciting event. The central theory of pancreatitis revolves around the activation of intrapancreatic trypsinogen, resulting in acinar cell damage and cytokines and other pro‐inflammatory markers that play a role in the subsequent systemic inflammatory response that results in tissue damage.⁵ In the majority of patients, the process is self‐limiting. However, in some patients, the disease process accelerates rapidly and can lead to pancreatic necrosis and generalized organ failure. Pancreatic necrosis can sometimes become infected by gut bacteria, which further increases the risk of mortality.