Читать книгу Drug Transporters - Группа авторов - Страница 100

According to the FDA, if the ratio of unbound drug Cmax concentration divided by the IC₅₀ or K _i value for transporter inhibition is ≥0.1, there is potential for an in vivo drug interaction. This section highlights drug interaction studies that have been conducted in humans and evaluated for pharmacokinetic alterations of MATE substrates in the presence of inhibitors (Table 3.4).