Читать книгу Herpetic keratitis: from symptoms to recovery - - Страница 8

Genetic Predisposition:

– Polymorphisms in genes such as IL-1B and IFNL3 are associated with the severity of inflammation.

Role of the Microbiota:

– Alterations in the ocular surface microbiome influence the frequency and intensity of recurrences.

Epigenetics:

– Epigenetic modifications of viral and host cellular DNA may determine susceptibility to reactivation.

Conclusion:

The staged pathogenesis of HSV keratitis highlights the importance of viral latency and reactivation triggers as key factors governing recurrences and disease severity. The combination of direct cytotoxic viral effects and an excessive immune response shapes the clinical picture, necessitating a balanced therapeutic approach.