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The working of all the organs and systems is regulated by the central nervous system (CNS) and the autonomic nervous system (ANS).

It is possible to draw an analogy between the working of the body and the playing of a symphony orchestra. The finest movements of dozens of people in the orchestra are in total harmony; they are following the same part and respond sensitively to the tiniest direction from the conductor. You could single out the viola or oboe part, and they would sound like part of one beautiful melody.

It is the same in the body: each organ and each system plays its role, but they are all following one rhythm, one autonomous control.

But then one of the violins loses the rhythm, falling out of time with the overall control system. This goes unnoticed by the untrained ear, and only an experienced listener will hear the wrong note. The melody will sound, but the greater the number of instruments which fall out of line with the control system, the stronger and more noticeable the dissonance will be, until finally even the most uneducated listener will start to wince and slowly creep out of the concert hall.

This analogy can be applied to the working of the body. As long as all systems and organs are working in harmony, in unison, following the same program, the body is at its optimal functioning level. Control and direction are ensured by two fundamental mechanisms:

•autonomic control by the nervous system (ANS), including neurohumoral regulation of activity;

•electron control through active forms of oxygen in the blood.

It could be said that this control is the base level, making it possible to detect all external impacts and react to them instantly, supporting Homeostasis and the relative constancy of the body’s internal environment.

If a person runs about and makes a few sudden movements, and the ANS increases the frequency of the heart’s contractions, then breathing speeds up, increasing respiration. More oxygen gets into the blood, and this oxygen is more actively conveyed to the tissues, with some of the by-products of the increase in respiration coming out in perspiration through the skin.

The reaction takes places almost instantaneously, and the whole body, all its systems and organs, are engaged by this reaction. This is evidence that all the organs and systems are working in a synchronized way under the control of a single commanding system. Everything happens as in a well-tuned orchestra.

When autonomic regulation fails and that synchronization is lost, the organs and systems stop working in harmony and functional abnormalities appear. In the first phases, these abnormalities appear as a bad state of health, disturbed sleep and digestion, and abnormalities with perspiration and so on. Continued dysfunction leads to abnormalities at the level of the organs, although the area of abnormality depends on the type of load and genetic predisposition.

This rather simplified diagram of fig.1.3 shows the general character of the body’s reactions and the development of diseases.

Reacting to commands coming from the CNS and the surrounding environment, the ANS and blood send information control signals to the body’s systems and organs. These signals are ‘processed’ both at the physiological level of systems and by engaging the endocrine and immune systems. Information is transferred to the controlling organs, forming a Biological Reverse System (BRS). In this way, a closed circuit of control is formed. When there is an abnormality in any one of the information links, the circuit fails and de-synchronization occurs, reflected in the functional abnormalities at all of the most vital levels.

Therefore, the autonomic nervous system enters into the first circuit of control, and the early signs of potential problems appear mainly at the level of ANS activity.

There is much experimental data which proves that the EPI method measures the activity of the autonomic nervous system. This is demonstrated by statistically significant correlations with the results of the measurements of the variability of cardiac rhythm [Cioca et al., 2004], of systolic and diasystolic pressure [Alexandrova et al, 2004], perspiration through the skin [Rizzo-Roberts, 2004], and the stress level [Bundzen et al, 2002]. The findings about the link between EPI data and ANS activity were first made in research on adaptation and homeostasis during work [Drozdov, Schatsillo, 2005] and subsequent results confirmed these findings.

There is clearly justification for affirming that the parameters of EPI images reflect the activity of the autonomic nervous system and the balance of sympathetic and parasympathetic sections of this system.