Читать книгу Complementary and Alternative Medicine (CAM) Supplement Use in People with Diabetes: A Clinician's Guide - Laura Shane-McWhorter - Страница 17

A study in Pakistan in 60 individuals with type 2 diabetes who were taking sulfonylureas found that cinnamon improved glucose and lipids.⁶⁵ Patients were given 1, 3, or 6 g/day cinnamon or placebo for 40 days. Fasting blood glucose declined by 18–29% after 40 days in all three groups. At a dose of 1 g/day, glucose decreased from a baseline of 209 mg/dl (11.6 mmol/l) to 157 mg/dl (8.7 mmol/l); at 3 g/day, glucose decreased from 205 mg/dl (11.4 mmol/l) to 169 mg/dl (9.4 mmol/l); and at 6 g/day, glucose decreased from 234 mg/dl (13.0 mmol/l) to 166 mg/dl (9.2 mmol/l) (P < 0.05 for all three groups vs. baseline). Cinnamon was withheld for the next 20 days, and fasting glucose was still lower than at baseline, indicating that cinnamon had a sustained benefit. Improvements in lipids were also significant. Total cholesterol decreased by 12–26%, triglycerides decreased by 23–30%, and LDL cholesterol also declined by 7–27% (P < 0.05 for all three parameters). HDL cholesterol did not improve, and the authors did not report changes in A1C.

Another study was done in Germany in 79 individuals with type 2 diabetes being treated with oral agents or diet.⁶⁶ This 4-month randomized double-blind, placebo-controlled trial evaluated use of an aqueous cinnamon extract, essentially devoid of coumarins (<0.1%) and thought to be less allergenic than other forms. Patients were randomized to a placebo or a capsule containing 1 g cinnamon three times a day. In the cinnamon group, mean baseline fasting glucose decreased from 167 mg/dl (9.3 mmol/l) to 147 mg/dl (8.2 mmol/l) after 4 months (P < 0.001). The placebo group had a decrease from mean baseline of 156 mg/dl (8.7 mmol/l) to 150 mg/dl (8.3 mmol/l; results not significant). The mean percentage difference was 10.3% in the treatment group and 3.37% in the placebo group (P = 0.046). Mean baseline A1C did not decrease significantly. Mean A1C declined from a baseline of 6.86% to 6.83% in the cinnamon group and from 6.71% to 6.68% in the placebo group. There were no differences in lipids. Mean baseline LDL cholesterol was 134 mg/dl (3.5 mmol/l) and 135 mg/dl (3.5 mmol/l) at end point in the cinnamon group. The mean baseline and end point LDL cholesterol did not change in the placebo group and was 138 mg/dl (3.6 mmol/l).