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CONTENTS

List of Illustrations

Preface

Acknowledgments

Abbreviations

THE EXPERIMENT BEGINS

ONE. Medical Research Past and Present

PERCEPTIONS

TWO. East African Perceptions of Medical Research

RESEARCHERS ARRIVE

HISTORICAL NARRATIVE: “Inspeakable Entomologists”

H. H. Goiny and a Failed Attempt to Eliminate Lymphatic Filariasis, Pate Island, Kenya, 1956

MODERN NARRATIVE: A “Remarkable Achievement”?

Lymphatic Filariasis Elimination, Zanzibar, 2001

THREE. First Encounters, First Impressions

CONSENT OR COERCION?

HISTORICAL NARRATIVE: “Forced to Accept Trial Treatment”?

A Tuberculosis Drug Trial, Nairobi, Kenya, 1961

MODERN NARRATIVE: Focusing on Fieldworkers in Kilifi, Kenya

FOUR. Ethical Recruitment and Gathering Human Subjects

BALANCING RISKS AND BENEFITS

HISTORICAL NARRATIVE: Hope Trant and a Compound on Fire in Tanganyika, 1954

MODERN NARRATIVE: A Male Circumcision Trial Canceled in Rakai, Uganda, 2005

FIVE. Finding an Ethical Balance

EXITS AND LONGER-TERM OBLIGATIONS

HISTORICAL NARRATIVE: “Almost Completely Eradicated”

The Pare-Taveta Malaria Scheme, 1955

MODERN NARRATIVE: A New Malaria Vaccine?

Testing the RTS,S Vaccine across Africa, 2010

SIX. Coming to an Ethical End

THE EXPERIMENT ENDS?

SEVEN. Modern Medical Research and Historical Residue

Appendix A. Swahili Glossary

Appendix B. Further Reading on Global Medical Research

Notes

Bibliography

Index