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Transporting Thyroid Hormone

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Most of the thyroid hormone in the body is carried around the bloodstream attached to special transport proteins, especially thyroid-binding globulin (TBG). Once the bound thyroid hormone reaches its destination, it is released from the protein binding so that T4 can be converted to T3 and ready for use by the cells. A tiny amount – around 0.03 per cent of T4 and 0.3 per cent of T3 – remains unattached to float freely about in the blood. Although only a small quantity, free-floating T3 does not have to be released from any binding and so is immediately available for use by the cells.

Certain conditions, such as taking the Pill, can raise the levels of protein in the blood and, in the past, thyroid tests which measured total levels of T4 and T3 were not always accurate because of some confusion in interpreting results. Today’s blood tests measure levels of both free-floating T4 and bound T4 as well as thyroid-stimulating hormone, which provide a much more accurate indication of thyroid function.

The Healthy Thyroid: What you can do to prevent and alleviate thyroid imbalance

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