Читать книгу Shear's Cysts of the Oral and Maxillofacial Regions - Paul M. Speight - Страница 45

Three elements are needed:

 A source of epithelium

 A stimulus for epithelial proliferation

 A mechanism of growth and bone resorption

The cyst develops in three phases:

 Phase of initiation – rest cells of Malassez are stimulated to proliferate within a periapical granuloma

 Phase of cyst formation – a cavity within the granuloma becomes lined by proliferating epithelium

 Phase of growth and enlargement – growth and enlargement are driven by increased osmotic pressure, and are associated with inflammation, cell proliferation and bone resorption

It is convenient first to consider the pathology of periapical periodontitis and then to discuss the pathogenesis of radicular cysts in three phases: the phase of initiation, the phase of cyst formation, and the phase of growth and enlargement.