Читать книгу Oral Cells and Tissues - Philias R. Garant - Страница 6

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Table of Contents

Preface

1 Early Tooth Development

Role of the Neural Crest

Development of the Dental Lamina, Enamel Organ, and Dental Papilla

Epithelial-Ectomesenchymal Morphogenetic Regulation of Odontogenesis

Growth and Differentiation Factors That Regulate Tooth Formation

Establishing Coronal Form (Cusp Formation)

Basic Science Correlations

Clinical Correlation: The Human Dentition

2 Dentin

Differentiation of Odontoblasts

Secretion of Dentin Matrix

Structure of Mature Secretory Odontoblasts

Composition of the Dentin Matrix

Mineralization of Mantle and Circumpulpal Dentin

Structure of the Odontoblastic Process and Dentinal Tubules

Formation of Intertubular and Peritubular Dentin

Transport Across the Odontoblastic Layer

Innervation of Dentin and Mechanisms of Pain Sensation

Supply of Blood to the Pulp

Cells and Extracellular Matrix of the Dental Pulp

Basic Science Correlation: The Secretory Pathway

Clinical Correlations

3 Enamel

Differentiation of the Enamel Organ

Structure of Secretion-Stage Ameloblasts

Biology of the Enamel Matrix

Location and Expression of Amelogenin, Ameloblastin, and Tuftelin Genes

Mineralization of the Enamel Matrix

Structure of Transition-Stage Ameloblasts

Formation of the Papillary Layer

Structure of Maturation-Stage Ameloblasts

Structure of Postmaturation-Stage Ameloblasts

Basic Science Correlations

Clinical Correlations

4 Oral Mucosa

Cell Proliferation and Differentiation in Stratified Squamous Epithelia

Structure and Function of the Cornified (Orthokeratinizing) Epithelium: The Epidermal Model

Differentiation of the Oral Mucosa

Basic Science Correlations

Clinical Correlations

5 Gingiva

Epithelial Components of the Gingiva

Expression of Keratins in Gingiva

Expression of Cell Surface Adhesion Molecules in Gingiva

Formation of Dental Cuticles

Organization of Gingival Connective Tissue

Supply of Blood to the Gingiva

Innervation of the Gingiva

Flow and Composition of Gingival Crevicular Fluid

Basic Science Correlations

Clinical Correlations

6 Periodontal Ligament

Development and General Structure of the Periodontal Ligament

Components of the Extracellular Matrix

Supply of Blood to the Periodontal Ligament

Innervation of the Periodontal Ligament

Basic Science Correlations

Clinical Correlations

7 Root Formation and Cementogenesis

Development of the Roots

Cementogenesis in Animal Models

Cementogenesis in Humans

Responsiveness of Cementum

Matrix Proteins, Adhesion Molecules, and Growth Factors of Cementum

Process of Tooth Eruption

Basic Science Correlation: Construction of the Attachment

Clinical Correlation: Cementum Hypoplasia

8 Bone

Types and Functions of Osteogenic Cells

Components of the Bone Matrix

Development and Function of Osteoclasts

Inhibition of Osteoclastic Bone Resorption

Coupling of Bone Formation and Resorption

Influence of Parathyroid Hormone and Calcitonin on Bone Cells

Influence of Growth Factors and Cytokines on Bone Cells

Architecture of the Bone and Replacement of Osteons

Repair of the Bone

Anatomic Characteristics of the Jawbones

Turnover and Remodeling of Alveolar Bone

Basic Science Correlations

Clinical Correlations

9 Salivary Glands

General Composition of a Gland

Development of the Salivary Glands

Basic Structure of Serous and Mucous Cells

Secretion of Saliva

Resynthesis of Proteins

Composition of Saliva

Nonsecretory Components of the Salivary Glands

Structure of the Major Glands

Innervation and Neural Control of Salivary Secretion

Basic Science Correlations

Clinical Correlations

10 Oral Somatosensory Systems

Types of Cutaneous Somatosensory Receptors

Innervation of the Oral Mucosa

Theories of Somatosensory Perception

Innervation and Sensation of the Pulp and Dentin

Nerve Regeneration Following Tooth Extraction

Peptidergic Nerve Endings in Pulp and Gingiva

Basic Science Correlations

Clinical Correlations

11 Muscle

Muscles of Mastication

Muscles of the Tongue, Soft Palate, and Pharynx

Development of Skeletal Muscle

Structure of Skeletal Muscle

Mastication

Structure of Smooth Muscle

Basic Science Correlations

12 Cartilage and Temporomandibular Joint

Development and Structure of Cartilage

Components of the Temporomandibular Joint

Clinical Correlation: Pathoses of the Temporomandibular Joint

13 Immune System

Initiation of Immune Response

Development of T Lymphocytes

Structure of T-Cell Receptors

Structure of Major Histocompatibility Complex Molecules

Processing and Presentation of Antigenic Peptides

Activation of T Cells

Function of Helper T Cells

Function of Cytolytic T Lymphocytes and Classic Natural Killer Cells

Development of B Lymphocytes

Activation of B Cells

Non–Antigen-Specific Activation of T and B Cells

Development of Immunologic Tolerance

Structure and Function of Plasma Cells

Initiation of Serum Antibody Response

Lymphocyte Circulation from Bone Marrow to Secondary Lymphoid and Peripheral Tissues

Role of Keratinocytes in the Immune Response

Role of Dendritic Cells and Langerhans Cells

Basic Science Correlations

Clinical Correlation: Immune Response in Gingival and Periodontal Disease

14 Phagocytic Cells

Development of Polymorphonuclear Neutrophils

Role of Polymorphonuclear Neutrophil Cell Surface Receptors

Activation of Polymorphonuclear Neutrophils

Development and Structure of Monocytes and Macrophages

Types of Monocyte and Macrophage Receptors

Activation of Monocytes

Transmigration of Phagocytic Cells

Chemotaxis

Phagocytosis

Generation of Reactive Oxygen Metabolites

Antimicrobial Agents of Phagocytes

Role of Phagocytes in Regulating Inflammation

Aggregation of Polymorphonuclear Neutrophils

Cytokine Regulation of Phagocytic Cells

Structure and Function of the Complement System

Biologic Effects of Lipopolysaccharide

Glucocorticoid Modulation of the Inflammatory Response

Immunomodulatory Evasion Mechanisms of Microbes

Clinical Correlation: Polymorphonuclear Neutrophil Function and Periodontal Disease

Oral Cells and Tissues

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