Читать книгу Oral Pathology in Clinical Dental Practice - Robert E. Marx - Страница 183

Field cancerization histopathology is no different than that of isolated dysplasia, carcinoma in situ, and invasive squamous cell carcinoma that represent focal disease, in which atypical epithelial cells with pleomorphic nuclei and mitotic figures occur above an intact basement membrane and then invade through the basement membrane to the subjacent connective tissue, sometimes forming keratin pearls and other times more anaplastic features.