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Главная Авторы S. Jane Flint Principles of Virology, Volume 2

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Principles of Virology, Volume 2

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Страница 1 Table of Contents List of Tables List of Illustrations Guide Pages VOLUME II Pathogenesis and Control PRINCIPLES OF
Virology Страница 8Страница 9 About the Instructor Companion Website Страница 11 Acknowledgments About the Authors Key of Repetitive Elements 1 Infections of Populations: History and Epidemiology LINKS FOR CHAPTER 1 Introduction to Viral Pathogenesis PRINCIPLES Introduction to viral pathogenesis A Brief History of Viral Pathogenesis The Relationships among Microbes and the Diseases They Cause BOX 1.1 DISCUSSION Why viruses may not fulfill Koch’s postulates The First Human Viruses Identified and the Role of Serendipity BOX 1.2 BACKGROUND Mosquito control measures New Methods Facilitate the Study of Viruses as Causes of Disease Viral Epidemics in History BOX 1.3 METHODS Nanopore sequencing Epidemics Shaped History: the 1793 Yellow Fever Epidemic in Philadelphia Tracking Epidemics by Sequencing: West Nile Virus Spread to the Western Hemisphere Zoonotic Infections and Epidemics Caused by “New” Viruses The Economic Toll of Viral Epidemics in Livestock Population Density and World Travel Are Accelerators of Viral Transmission Focus on Frontline Health Care: Ebolavirus in Africa Emergence of a Birth Defect Associated with Infection: Zika Virus in Brazil Epidemiology Fundamental Concepts Incidence versus Prevalence BOX 1.4 DISCUSSION Video games model infectious-disease epidemics Prospective and Retrospective Studies BOX 1.5 TERMINOLOGY Morbidity, mortality, incidence, and case fatality Mortality, Morbidity, and Case Fatality Ratios R-naught (R₀) Methods Used by Epidemiologists Surveillance BOX 1.6 METHODS The use of statistics in virology BOX 1.7 BACKGROUND Descriptive epidemiology and the discovery of human immunodeficiency virus BOX 1.8 METHODS Network Theory and Practical Applications Parameters That Govern the Ability of a Virus to Infect a Population Geography and Population Density BOX 1.9 DISCUSSION A virus on the move Climate BOX 1.10 EXPERIMENTS Temperature influences the transmission of influenza virus BOX 1.11 BACKGROUND BOX 1.12 DISCUSSION Plant virus epidemiology Perspectives BOX 1.13 DISCUSSION This moment in time: the SARS-CoV-2 pandemic REFERENCES Books Review Articles Papers of Special Interest STUDY QUESTIONS 2 Barriers to Infection LINKS FOR CHAPTER 2 Introduction An Overview of Infection and Immunity A Game of Chess Played by Masters PRINCIPLES Barriers to infection BOX 2.1 TERMINOLOGY Is it evasion or modulation? Initiating an Infection Successful Infections Must Modulate or Bypass Host Defenses Skin Respiratory Tract BOX 2.2 EXPERIMENTS Dermal damage increases immunity and host survival BOX 2.3 DISCUSSION In praise of mucus Alimentary Tract BOX 2.4 EXPERIMENTS Olfactory neurons: front-line sentinels BOX 2.5 EXPERIMENTS Commensal bacteria aid virus infections in the gastrointestinal tract Eyes Urogenital Tract Placenta Viral Tropism BOX 2.6 DISCUSSION Is intuition a host defense? Accessibility of Viral Receptors Other Host-Virus Interactions That Regulate the Infectious Cycle BOX 2.7 DISCUSSION A mechanism for expanding the tropism of influenza virus is revealed by analyzing infections that occurred in 1940 Spread throughout the Host BOX 2.8 DISCUSSION Gender differences in infection and disease Hematogenous Spread BOX 2.9 TERMINOLOGY The viruses in your blood Neural Spread BOX 2.10 TERMINOLOGY Infection of the nervous system: definitions and distinctions Organ Invasion Entry into Organs with Sinusoids Entry into Organs That Lack Sinusoids BOX 2.11 TERMINOLOGY Which direction: anterograde or retrograde? Organs with Dense Basement Membranes Skin Shedding of Virus Particles Respiratory Secretions Saliva Feces BOX 2.12 DISCUSSION A ferret model of influenza virus infection ignites irrational fears Blood Urine Semen Milk Skin Lesions Tears Perspectives BOX 2.13 DISCUSSION Chicken pox parties REFERENCES Books Review Articles Papers of Special Interest STUDY QUESTIONS {buyButton}

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