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Bone lining cells—effector cells on standby

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Bone lining cells originate from the same lineage as osteoblasts. They are mononucleated, flattened cells found lining surfaces in areas where there is no active bone formation (Figure 3.17b). They are believed to be a source of already committed osteogenic cells, known as dormant osteoblasts. They can be reactivated to the secreting form with the proper stimulus and under conditions that warrant active bone formation such as during mechanical stimulation, remodeling, and fracture repair (Miller, de Saint‐Georges, Bowman, & Jee, 1989).

Musculoskeletal Disorders

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