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The sudden appearance of a lump, skin changes, or nipple changes suggests cancer. This applies to men as well as women.

These changes include:

•A spontaneous clear or bloody discharge from one nipple with or without an associated breast lump

•A sudden retraction or indentation of one nipple

•A change in the size or shape of one breast

•Indentation, flattening, retraction of the skin of the breast

•Persistent nipple rash known as Paget’s disease of the nipple, also called Paget’s disease of the breast, is an uncommon (less than five percent) type of malignancy that forms in or around the nipple

•Localized breast redness

•Pitting of the skin of the breast so its appearance looks like the skin of an orange

Any one or combination of the above mandates a physician evaluation and diagnostic studies to rule out breast cancer.