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Tamilvanan Shunmugaperumal
Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
OIL‐IN‐WATER NANOSIZED EMULSIONS FOR DRUG DELIVERY AND TARGETING
Страница 8
Страница 9
LIST OF CONTRIBUTORS
FOREWORD
PREFACE
CHAPTER 1 INTRODUCTION: AN OVERVIEW OF NANOSIZED EMULSIONS
EXPANSION OF ABBREVIATIONS
1.1. INTRODUCTION
1.1.1. Nanotechnology: Definition
1.1.1.1. Poorly Water‐Soluble Grease Ball and Brick Dust Molecules
1.1.2. Nanosized Emulsions
1.1.2.1. Nanosized Emulsions: Prime Candidates for Nanoparticle Engineering
1.1.2.2. Ostwald Ripening‐Adapted Droplet Destabilization Process for the Greater Stability of Nanosized Emulsions
1.1.2.3. Classification of Oil‐in‐Water Nanosized Emulsions
1.2. CONCLUSION
REFERENCES
CHAPTER 2 FORMULATION DEVELOPMENT OF OIL‐IN‐WATER NANOSIZED EMULSIONS
EXPANSION OF ABBREVIATIONS
2.1. INTRODUCTION
2.2. FDA‐APPROVED OILS, EMULSIFIERS, AND AUXILIARY OR MISCELLANEOUS EXCIPIENTS
2.2.1. Issues Related to Oil Selection to Make the O/W Nanosized Emulsions for Medical Application
2.2.2. Issues Related to Emulsifier Selection to Stabilize the O/W Nanosized Emulsions for Medical Application
2.2.3. Importance of Charge‐Stabilized Nanosized Emulsions
2.2.4. Importance of Neutral‐Charged (Sterically Stabilized) Nanosized Emulsions
2.2.5. Advantages of Nanosized Emulsions Stabilized by Mixed or Multicomponent Emulsifier Molecules
2.2.6. “Stealth” Property of Nanosized Emulsions: In Vitro Demonstrations
2.2.7. Advantages of Stabilizers in Nanosized Emulsions
2.2.8. Miscellaneous Additives
2.3. CURRENT AND NEAR FUTURE DIRECTION 2.3.1. Colloidal Particle‐Stabilized Emulsions
2.4. LIPOPHILIC API INCORPORATION PATTERN INTO NANOSIZED EMULSIONS
2.4.1. Extemporaneous API Addition
2.4.2.
De Novo Emulsion Preparation
2.4.3. Interfacial Incorporation Approach
2.4.4. Incorporation of Antibodies, DNA Protein, Oligonucleotide, or Heat Labile Molecules
2.5. QbD APPROACH TO OPTIMIZE EMULSION
2.5.1. Case Study for Optimizing Systematically a Formula to Make O/W Nanosized Emulsions
2.5.1.1. Initial Quality Risk Assessment Studies
2.5.1.2. Factor Screening Study
2.5.1.3. Factor Screening Studies by Taguchi Design
2.5.1.4. Formulation Optimization by QbD: Experimental Design
2.5.1.5. Systematic Optimization Using Face‐Centered CCD
2.5.1.6. Response Surface Plot Analysis
2.5.1.7. Optimization of Responses for Formulation of CsA‐Loaded Nanosized Emulsion
2.6. CONCLUSION
REFERENCES
Note
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