Читать книгу Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting - Tamilvanan Shunmugaperumal - Страница 15

Inadequacy is the term that influences in every corner of modern scientific world. Starting from clothes, food, water, and shelter for covering the basic needs of living to affordable medicines for managing any ailments, the inadequacy plays major roles to judge the standard living of every country in the world. In the present scenario of democratic countries like India, USA, etc., the political party which acquires the adequate number of parliamentary members either elected by highest number of people votes in the constituency or after election shuffling with opposite party, is able to form the government for ruling the country another 3 or 5 years. Here too the adequacy means a lot to form the government and the inadequacy leads the party to sit opposite to ruling party. Coming to the affordable medicines, the presence of adequate amount of active pharmaceutical ingredient (API) in a dosage form becomes the prime importance to elicit the desired and often required pharmacological activity following administration of the same into human body. But achieving the adequate amount of API in the particular dosage form requires a lot of formulation knowledge input. How to manufacture the dosage form with adequate amount of API? The answer to this query primarily depends on solubility of API followed by its permeability, molecular size, therapeutic index, etc. If the water solubility of API is low, then, the enhancement of API’s solubility becomes a major concern in pharmaceutical industries for converting the inadequate API aqueous solubility amount into adequate category. This type of converting the API amount from inadequate to adequate category needs the tremendous supports from formulation scientist who has the experience to solve this concern. The lucrative way adapted routinely in the pharmaceutical industry for deleting the word inadequate from the API aqueous solubility is just to combine the API with a suitable nanosized API delivery system or just to pulverize or micronize the API into nano‐level size ranges. This book accentuates the use of one of the nanosized API delivery system to erase the inadequate aqueous solubility from API. Before proceeding with the nanosized API delivery system, a brief history of nanotechnology is being described below.