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Protein Folding and Degradation

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Translating the information in an mRNA into a polypeptide chain is only the first step in making an active protein. To be active, the polypeptide must fold into its final conformation. This is the most stable state of the protein and is determined by the primary structure of its polypeptides. Whereas some proteins fold efficiently into their active states, other proteins may need the assistance of other factors to increase the rate of folding into the active state and to prevent misfolding into an inactive state.

Snyder and Champness Molecular Genetics of Bacteria

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