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Magnesium

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Like potassium, the kidney functions to excrete magnesium from the body. A kidney that is impaired by acute or chronic disease may lose its ability to conserve magnesium, while ESRD implies loss of ability to excrete magnesium. Thus, hypomagnesemia can occur in kidney disease and hypermagnesemia in ESRD. A patient with a magnesium disturbance may have an arrhythmia or ECG abnormality, often related to QT interval changes. Classically, patients with low magnesium have increased reflexes and weakness with a prolonged Qtc interval. Hypermagnesemia is associated with hyporeflexia, mental status changes, and respiratory depression progressing to cardiac arrest. ECG findings may mimic hyperkalemia with peaked T‐waves, QRS widening, and possibly complete heart block [4,16].

Table 22.1 ECG changes in hyperkalemia

Peaked T‐waves Slow atrial fibrillation
PR prolongation Sine wave
Wide unusual QRS complexes Asystole
Conduction blocks Ventricular fibrillation
Bradycardia Wide complex pulseless electrical activity
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