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Table of Contents

Cover

Title Page

Copyright

Acknowledgements

Preface to the First Edition

Preface to the Second Edition

CHAPTER 1: Introduction to Critical Appraisal The aims of critical appraisal Three stages of critical appraisal

CHAPTER 2: Do Not Read the Paper The initial interrogation The in‐depth interrogation

CHAPTER 3: Identifying the Research Design Surveys Cohort studies Case–control studies RCTs Cohort studies that evaluate the effectiveness of interventions Systematic reviews

10  CHAPTER 4: Interpreting the Results The effect size Taking the play of chance into account Factors that distort the effect size Questionable research practices Conclusion

11  CHAPTER 5: The In‐Depth Interrogation Bias Critical questions for bias Important questions for bias Indicative questions for bias Questions about value Conclusion

12  CHAPTER 6: Appraising Surveys The critical bias questions for bias The complete list for appraising surveys*

13  CHAPTER 7: Appraising Cohort Studies The critical questions for bias The important questions for bias The indicative questions for risk of bias The complete list for the appraisal of cohort studies*

14  CHAPTER 8: Appraising Case–Control Studies The critical questions for bias The important questions for bias The complete list for the appraisal of case–control studies*

15  CHAPTER 9: Appraising Randomised Controlled Trials The critical questions for bias The important questions for bias The questions of value The complete list for the appraisal of clinical trials*

16  CHAPTER 10: Cohort Studies That Evaluate the Effectiveness of Interventions Overview of advantages of cohort treatment studies and challenges for critical appraisal The critical questions for bias The important questions for bias The questions of value Conclusion The complete list for the appraisal of cohort studies that evaluate interventions

17  CHAPTER 11: Appraising Systematic Reviews The critical questions for risk of bias The important questions for risk of bias The questions of value The complete list for the appraisal of systematic reviews*

18  CHAPTER 12: Summarising Risk of Bias Identify the risk of bias of the research designs Review the biases in study design, conduct, and interpretation Derive an overall rating Summary

19  CHAPTER 13: Certainty of Evidence The nature of certainty of evidence Downgrading the certainty of evidence Factors that increase certainty Overall assessment of certainty Conclusion

20  CHAPTER 14: Assessing Value Measuring potential benefit Harm and the balance between benefit and harm Costs and cost effectiveness Feasibility of implementation of a treatment Health equity Summary

21  Appendix: Further Reading Chapter 1: Introduction Chapter 3: Identifying the research design Chapter 4: Interpreting the results Chapter 5: The in‐depth interrogation Chapter 6: Appraising surveys Chapter 7: Appraising cohort studies Chapter 8: Appraising case–control studies Chapter 9: Appraising randomised controlled trials Chapter 10: Cohort studies that evaluate the effectiveness of interventions Chapter 11: Appraising systematic reviews Chapter 12: Summarising risk of bias Chapter 13: Certainty of evidence Chapter 14: Assessing value

22  Index

23  End User License Agreement

List of Tables

1 Chapter 12TABLE 12.1 Initial ranking of the research designs.TABLE 12.2 Illustration of an assessment of risk of bias in an RCT.

Guide

Cover Page

Table of Contents

Title Page

Copyright

Acknowledgements

Preface to the First Edition

Preface to the Second Edition

Begin Reading

Appendix: Further Reading

10  Index

11  Wiley End User License Agreement

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The Pocket Guide to Critical Appraisal

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