Читать книгу Anti-Aging Therapeutics Volume XV - A4M American Academy - Страница 23

HGH

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Aberg ND. Growth hormone increases connexin-43 expression in the cerebral cortex and hypothalamus. Endocrinology 2000 Oct; 141(10):3879-86

Abs R. Update on the diagnosis of GH deficiency in adults. Eur J Endocrinol. 2003 Apr; 148 Suppl 2:S3-8.

Adamopoulos S et al. Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy. Am Heart J 2002 Aug;144(2):359-64

Aimaretti G et al. Diagnostic reliability of a single IGF-I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency.Clin Endocrinol (Oxf). 2003 Jul; 59(1):56-61

Albert SG et al. Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity.Clin Endocrinol Metab. 2004 Feb; 89(2):695-701.

Aleman et al. Insulin-Like Growth Factor-I and Cognitive Function in Healthy Older Men J Clin Endocrinol Metab 84:471–475, 1999

Andreassen et al. Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency. Clin Endocrinol (Oxf). 2007 Aug 28

Baffa R et al. Low serum insulin-like growth factor 1 (IGF-1): a significant association with prostate cancer. Tech Urol 2000 Sep; 6(3):236-239

Bartke A et al. Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 2002 Apr;36(2-3):201

Baum HB et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann Intern Med 1996 Dec 1; 125(11):883-90

Bengtsson BA, Edén S, Lönn L, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab. 1993;76:309-317.

Bennett R Growth hormone in musculoskeletal pain states.Curr Rheumatol Rep. 2004 Aug; 6(4):266-73.

Bennett RM et al. A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia Am J Med. 1998 Mar; 104(3):227-31.

Besson A et al. Reduced longevity in untreated patients with isolated growth hormone deficiency. J Clin Endocrinol Metab. 2003 Aug; 88(8):3664-7.

Biller BM et al. Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab. 2002 May; 87(5):2067-79.

Blackman M et al. Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men. JAMA November 13, 2002. Vol 288 No 18.

Bocchi EA et al. Growth hormone for optimization of refractory heart failure treatment. Arq Bras Cardiol 1999 Oct; 73(4):391-8

Bogarin R et al. Growth hormone treatment and risk of recurrence or progression of brain tumors in children: a review. Childs Nerv Syst. 2009 Jan 14

Boguszewski CL, Meister LH, Zaninelli DC, Radominski RB. One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults. Eur J Endocrinol. 2005;152:67-75.

Bohdanowicz-Pawlak A et al. Risk factors of cardiovascular disease in GH-deficient adults with hypopituitarism: a preliminary report. Med Sci Monit. 2006 Feb; 12(2):CR75-80.

Borson-Chazot F. et al. Decrease in Carotid Intima-Media Thickness after One Year Growth Hormone (GH) Treatment in Adults with GH Deficiency J Clin Endocrinol Metab 84: 1329–1333, 1999

Branski LK et al. Randomized Controlled Trial to Determine the Efficacy of Long-Term Growth Hormone Treatment in Severely Burned Children., Ann Surg. 2009 Sep 2

Burgess W et al. The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I. Neuroimmunomodulation 1999 Jan-Apr; 6(1-2):56-68

Caidahl K, Edén S, Bengtsson BA. Cardiovascular and renal effects of growth hormone. Clin Endocrinol (Oxf). 1994;40:393-400.

Cappola AR et al. Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab 2001 Sep; 86(9):4139-46

Cappola et al. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women JCEM, 2003 May; 88(5):2019-25.

Cenci MC, Soares DV, Spina LD, Brasil RR, Lobo PM, Michmacher E, Vaisman M, Boguszewski CL, Conceição FL. Comparison of two dose regimens of growth hormone (GH) with different target IGF-1 levels on glucose metabolism, lipid profile, cardiovascular function and anthropometric parameters in gh-deficient adults. Growth Horm IGF Res. 2012;22:116-121.

Chan et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science Vol 279 January 1998

Cherbonnier C et al. Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-kappaB activity. Br J Cancer. 2003 Sep 15;89(6):1108-15

Christiansen, J. Influence of growth hormone and androgens on body composition in adults. Horm Res. 1996; 45(1-2):94-8

Colao A et al. Beginning to end: Cardiovascular implications of growth hormone (GH) deficiency and GH therapy. Growth Horm IGF Res. 2006 May 9

Colao A et al. Effect of growth hormone (GH) and insulin-like growth factor I on prostate diseases: an ultrasonographic and endocrine study in acromegaly. J Clin Endocrinol Metab 1999 Jun; 84(6):1986-91

Colao A et al. Impaired cardiac performance in elderly patients with growth hormone deficiency J Clin Endocrinol Metab 1999 Nov; 84(11):3950-5

Colao A, di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G. Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab. 2001;86:1874-1881.

Colao A.Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. J Clin Endocrinol Metab 1999 Jun; 84(6):1919-24

Collier SR et al. Growth hormone responses to varying doses of oral arginine.Growth Horm IGF Res. 2005 Apr; 15(2):136-9.

Cook DM.Shouldn't adults with growth hormone deficiency be offered growth hormone replacement therapy?Ann Intern Med 2002 Aug 6;137(3):197-201

Cook, D et al. Route of Estrogen Administration Helps to Determine Growth Hormone (GH) Replacement Dose in GH-Deficient Adults. J Clin Endocrinol Metab 1999Nov; 84: (11): 3956–3960,

Corpas E et al. Oral arginine-lysine does not increase growth hormone or insulin-like growth factor-I in old men. J Gerontol 1993 Jul; 48(4):M128-33

Cuatrecasas G et al. Growth hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels. BMC Musculoskelet Disord. 2007 Nov 30:

Cuatrecasas G, Alegre C, Fernandez-Solà J, Gonzalez MJ, Garcia-Fructuoso F, Poca-Dias V, Nadal A, Cuatrecasas G, Navarro F, Mera A, Lage M, Peinó R, Casanueva F, Liñan C, Sesmilo G, Coves MJ, Izquierdo JP, Alvarez I, Granados E, Puig-Domingo M. Growth hormone treatment for sustained pain reduction and improvement in quality of life in severe fibromyalgia. Pain. 2012 Jul;153(7):1382-9.

Drake W et al Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults. J Clin Endocrinol Metab 1998 Nov; 83(11):3913-9 Fazio et al. A preliminary study of GH in the treatment of dilated cardiomyopathy. NEJM 1996:334:809-814

Elbornsson M, Götherström G, Franco C, Bengtsson BÅ, Johannsson G, Svensson J. Effects of 3-year GH replacement therapy on bone mineral density in younger and elderly adults with adult-onset GH deficiency. Eur J Endocrinol. 2012 Feb;166(2):181-9.

Fiebig HH et al. No evidence of tumor growth stimulation in human tumors in vitro following treatment with recombinant human growth hormone Anticancer Drugs 2000 Sep;11(8):659-64

Follin C, Thilén U, Ahrén B, Erfurth EM. Improvement in cardiac systolic function and reduced prevalence of metabolic syndrome after two years of growth hormone (GH) treatment in GH-deficient adult survivors of childhood-onset acute lymphoblastic leukemia. J Clin Endocrinol Metab. 2006 May;91(5):1872-5.

Franco C et al. Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. J Clin Endocrinol Metab. 2005 Mar; 90(3):1466-74

Franco C, Andersson B, Lönn L, Bengtsson BA, Svensson J, Johannsson G. Growth hormone reduces inflammation in postmenopausal women with abdominal obesity: a 12-month, randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2007 Jul;92(7):2644-7.

French RA et al. Age-Associated Loss of Bone Marrow Hematopoietic Cells Is Reversed by GH and Accompanies Thymic Reconstitution Endocrinology Vol. 143, No. 2 690-699, Jan 2002

Frohman LA. Controversy about treatment of growth hormone-deficient adults: a commentary. Ann Intern Med. 2002 Aug 6;137(3):202-4.

Garten A, Schuster S, Kiess W. The insulin-like growth factors in adipogenesis and obesity. Endocrinol Metab Clin North Am. 2012 Jun;41(2):283-95,

Genth-Zotz S et al. Recombinant growth hormone therapy in patients with ischemic cardiomyopathy: effects on hemodynamics, left ventricular function, and cardiopulmonary exercise capacity. Circulation. 1999 Jan 5-12; 99(1):18-21

Ghigo E et al. Diagnosis of adult GH deficiency. Growth Horm IGF Res. 2008 Feb; 18(1):1-16.

Gibney et al. The effects of 10 years of GH in adult GH deficient patients J Endocrin Metab 1999 August

Gilchrist FJ et al. The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH-deficient adults. Clin Endocrinol (Oxf) 2002 Sep; 57(3):363-70

Gillberg, P. et al. Two Years of Treatment with Recombinant Human Growth Hormone Increases Bone Mineral Density in Men with Idiopathic Osteoporosis J Clin Endocrinol Metab 2002 87: 4900-4906

Gotherstrom G et al. A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass and metabolic indices. J Clin Endocrinol Metab 2001 Oct; 86(10):4657-65

Giustina A, Barkan A, Chanson P, Grossman A, Hoffman A, Ghigo E, Casanueva F, Colao A, Lamberts S, Sheppard M, Melmed S; Pituitary Society; European Neuroendocrine Association. Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults. J Endocrinol Invest. 2008 Sep;31(9):820-38. Review

Harris, et al. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med. 2003 Oct 15; 115(6):429-35.

Hedstrom M. Hip fracture patients, a group of frail elderly people with low bone mineral density, muscle mass and IGF-I levels. Acta Physiol Scand 1999 Dec; 167(4):347-50

Yusuke Higashi, Sergiy Sukhanov, Asif Anwar, Shaw-Yung Shai, Patrice Delafontaine. “Aging, Atherosclerosis, and IGF-1.” J Gerontol A Biol Sci Med Sci (2012) 67A (6): 626-639.

Ho KK et al. Regulating of growth hormone sensitivity by sex steroids: implications for therapy. Front Horm Res. 2006;35:115-28

Hong J et al.; IGFBP-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells. J Biol Chem 2002 Jan 9, 2002

Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y. Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer. J Biol Chem. 2010 Sep 24;285(39):30233-46.

Isgaard J et al.GH improves cardiac function in rats with experimental MI. Eur J Clin Invest 1997;27:517-

Isley WL. Growth hormone therapy for adults: not ready for prime time?Ann Intern Med 2002 Aug 6;137(3):190-6

Janssen, Y et al. A Switch from Oral (2 mg/Day) to Transdermal (50 mg/Day) 17b-Estradiol Therapy Increases Serum Insulin-Like Growth Factor-I Levels in Recombinant Human Growth Hormone (GH)-Substituted Women with GH Deficiency. J. Clin Endo Metab. 85: January 2000

Jenkins PJ, Mukherjee A, Shalet SM. Does growth hormone cause cancer? Clin Endocrinol (Oxf). 2006 Feb;64(2):115-21.

Johannsson G et al. GH treatment of abdominally obese men reduces abdominal fat mass, improves glusoce and lipoprotein metabolism and reduces diastolic BP. J Clin Endocinol Metab 1997;82:727-734

Johansen et al. Ipamorelin a new ghrp induces longitudinal bone growth in rats. GH and IGF Research 1999, 9 106-113

Johnsen P. et al. Insulin-Like Growth Factor (IGF) I, -II, and IGF Binding Protein-3 and Risk of Ischemic Stroke J Clin Endocrinol Metab 2005 90: 5937-5941;

Kelley KW, Brief S, Westly HJ, Novakofski J, Bechtel PJ, Simon J, Walker EB. GH3 pituitary adenoma cells can reverse thymic aging in rats. Proc Natl Acad Sci U S A. 1986;83:5663-5667.

Khansari DN et al. Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice. Mech Ageing Dev 1991 Jan; 57(1):87-100

Kishimoto I, Tokudome T, Hosoda H, Miyazato M, Kangawa K. Ghrelin and cardiovascular diseases. J Cardiol. 2012 Jan;59(1):8-13.

Kurek R et al. The significance of serum levels of insulin-like growth factor-1 in patients with prostate cancer BJU Int 2000 Jan; 85(1):125-9

Lang CH et al. Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance. Pediatr Nephrol. 2004 Nov 10

Laughlin GA et al. The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2004 Jan; 89(1):114-20

Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D. The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2004 Jan;89(1):114-20.

Leal-Cerro A The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome. J Clin Endocrinol Metab. 1999 Sep; 84(9):3378-81.

Liu H, Bravata DM, Olkin I, Nayak S, Roberts B, Garber AM, Hoffman AR. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med. 2007;146:104-115.

Liu QL, Wang YS, Wang JX. Effect of growth hormone on the immune function of dendritic cells. Chin Med J (Engl). 2010;123:1078-1083.

Longobardi, S et al Effects of two years of growth hormone (GH) replacement therapy on bone metabolism and mineral density in childhood and adulthood onset GH deficient patients. J Endocinol Invest, May 1999

Major J et al. Insulin-Like Growth Factor-I and Cancer Mortality in Older Men The Journal of Clinical Endocrinology & Metabolism Vol. 95, No. 3 1054-1059 March 2010

Marcell TJ et al. Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults. Gerontol A Biol Sci Med Sci 1999 Aug; 54(8):M395-9

Mitsi AC et al. Early, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarction. Growth Horm IGF Res. 2006 Apr; 16(2):93-100

Mitsi AC et al. Early, selective growth hormone administration may ameliorate left ventricular remodeling after myocardial infarction. Med Hypotheses. 2005; 64(3):582-5

Molitch ME. Diagnosis of GH deficiency in adults--how good do the criteria need to be? J Clin Endocrinol Metab. 2002 Feb;87(2):473-6.

Moyle GJ, Daar ES, Gertner JM, Kotler DP, Melchior JC, O'brien F, Svanberg E; Serono 9037 Study Team. Growth hormone improves lean body mass, physical performance, and quality of life in subjects with HIV-associated weight loss or wasting on highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2004 Apr 1;35(4):367-75.

Muniyappa R et al. Long-Term Testosterone Supplementation Augments Overnight Growth Hormone Secretion in Healthy Older Men. Am J Physiol Endocrinol Metab. 2007

Munzer T et al., Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. J Clin Endocrinol Metab 2001 Aug; 86(8):3604-10

Nam SY et al. Growth Hormone and Adipocyte Function in Obesity.Horm Res 2000 Jul; 53 Suppl S1:87-97

Nam SY et al. Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients. Int J Obes Relat Metab Disord 2001 Aug;25(8):1101-7.

Nam SY, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB. Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients. Int J Obes Relat Metab Disord. 2001 Aug;25(8):1101-7.

Napolitano LA, Schmidt D, Gotway MB, et al. Growth hormone enhances thymic function in HIV-1-infected adults. J Clin Invest. 2008;118:1085-1098.

Nguyen CT, Aaronson A, Morrissey RP, Agarwal M, Willix RD, Schwarz ER. Myths and truths of growth hormone and testosterone therapy in heart failure. Expert Rev Cardiovasc Ther. 2011;9:711-720.

Niikura, T et al. Insulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive Manner The Journal of Neuroscience, March 15, 2001, 21(6):1902-1910

Nyberg F. Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance. Front Neuroendocrinol 2000 Oct; 21(4):330-348

Perrot, A. et al. Growth Hormone Treatment in Dilated Cardiomyopathy J Card. Surg 2001; 16:127-131

Pfeifer M et al. Growth Hormone (GH) Treatment Reverses Early atherosclerotic Changes in GH-Deficient Adults J Clin Endocrinol Metab 84: 453–457, 1999

Popovic V, et al Growth Horm IGF Res. 2005 Jun; 15(3):177-84. 2005 Mar 21. Hypopituitarism following traumatic brain injury

Popovic, V et al. The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth hormone deficiency in adults. Clin Endocrinol (Oxf). 2003 Aug; 59(2):251-7

Ren J et al. Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease. J Mol Cell Cardiol 1999 Nov;31(11):2049-61

Rosén T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990;336:285-288.

Rousseau N et al. Effect of aging on growth hormone-induced insulin-like growth factor-I secretion from cultured rat chondrocytes Growth Regulation 7 (1) 1997

Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990;323:1-6.

Ruiz-Torres A et al. Ageing and longevity are related to growth hormone/insulin-like growth factor-1 secretion. Gerontology. 2002 Nov-Dec; 48(6):401-7

Ruiz-Torres A. and Soares de Melo Kirzner M. “Ageing and Longevity Are Related to Growth Hormone/Insulun-Like Growth Factor-1 Secretion.” Gerontology 2002; 48:401-507.

Sattler F et al. Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men. JCEM 2009 94:1991-2001 March 17

Sattler F et al. Testosterone Threshold Levels and Lean Tissue Mass Targets Needed to Enhance Skeletal Muscle Strength and Function: The HORMA Trial. J Gerontol A Biol Sci Med Sci. 2010 Nov 8.

Savine R. et al Growth hormone replacement for the somatopause. Horm Res 2000; 53 Suppl 3:37-41

Savino W, Smaniotto S, Mendes-da-Cruz DA, Dardenne M. Growth hormone modulates migration of thymocytes and peripheral T cells. Ann N Y Acad Sci. 2012;1261:49-54.

Schernhammer ES et al. Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II. Endocr Relat Cancer. 2006 Jun; 13(2):583-592

Schneider HJ, Klotsche J, Wittchen HU, et al. Effects of growth hormone replacement within the KIMS survey on estimated cardiovascular risk and predictors of risk reduction in patients with growth hormone deficiency. Clin Endocrinol (Oxf). 2011;75:825-830.

Scirè G, Del Bianco C, Spadoni GL, Cianfarani S. Growth hormone therapy does not alter the insulin-like growth factor-I/insulin-like growth factor binding protein-3 molar ratio in growth hormone-deficient children. J Endocrinol Invest. 2008 Feb;31(2):153-8.

Sesmilo G et al. Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. Ann Intern Med 2000 Jul 18; 133(2):111-22

Sesmilo G. et al. Effects of GH Administration on Homocysteine Levels in Men with GH Deficiency: A Randomized Controlled Trial. The Journal of Clinical Endocrinology & Metabolism Vol. 86, No. 4 1518-1524, 2001

Shalet SM, Brennan BM, Reddingius RE. Growth hormone therapy and malignancy. Horm Res 1997; 48 Suppl 4:29-32

Slonim AE et al. A preliminary study of growth hormone therapy for Crohn's disease. N Engl J Med 2000 Jun 1; 342(22):1633-

Soares DV, Spina LD, de Lima Oliveira Brasil RR, Lobo PM, Salles E, Coeli CM, Conceição FL, Vaisman M. Two years of growth hormone replacement therapy in a group of patients with Sheehan's syndrome. Pituitary. 2006;9(2):127-35.

Stochholm, K et al. Mortality and GH Deficiency a Nationwide Study. European Journal of Endocrinology. (2007)157 9-18

Strassberger C et al. How robust are laboratory measures of growth hormone status? Hormone Research 2005; 64:1-

Sugimoto T et al. Effect of recombinant human growth hormone in elderly osteoporotic women. Clin Endocrinol (Oxf) 1999 Dec; 51(6):715-724

Svensson J et al. Body composition and quality of life as markers of the efficacy of growth hormone replacement therapy in adults.Horm Res 2001;55 Suppl 2:55-60

Svensson J, Mattsson A, Rosén T, Wirén L, Johannsson G, Bengtsson BA, Koltowska Häggström M; Swedish KIMS National Board. Three-years of growth hormone (GH) replacement therapy in GH-deficient adults: effects on quality of life, patient-reported outcomes and healthcare consumption. Growth Horm IGF Res. 2004;14:207-215.

Swerdlow A. et al. Growth Hormone Treatment of Children with Brain Tumors and Risk of Tumor Recurrence. The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 12, December 2000

Takala J et al. Increased mortality associated with GH treatment in critically ill adults. NEJM 1999; 341:785-

Thum T et al. Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-1. J Clin Endocrinol Metab. 2007 Aug 28

Tivesten, A The Growth Hormone Secretagogue Hexarelin Improves Cardiac Function in Rats after Experimental Myocardial Infarction. Endocrinology, January 2000, p. 60-66 Vol. 141, No. 1

Toogood A. et al. Growth Hormone Replacement Therapy in the Elderly with Hypothalamic-Pituitary Disease: A Dose-Finding Study. J Clin Endocrinol Metab 84: 131–136, 1999

Torella D et al. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res. 2004 Mar 5;94(4):514-24

Zoltan Ungvari and Anna Csiszar. “The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances.” J Gerontol A Biol Sci Med Sci (2012) 67A (6): 599-610.

Valimaki MJ et alEffects of 42 months of GH treatment on bone mineral density and bone turnover in GH-deficient adults. Eur J Endocrinol 1999 Jun; 140(6):545-54

van Dam PS Somatropin therapy and cognitive function in adults with growth hormone deficiency: a critical review. Treat Endocrinol. 2006; 5(3):159-70

Van Der Lely et al. Use of human GH in elderly patients with accidental hip fracture. Eur J Endocrinol 2000 Nov; 143(5):585-592

Wang P et al. The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity. World J Gastroenterol 2002 Jun; 8(3):531-6 AIM:

Wren AM et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion, Endocrinology 2000 Nov;141(11):4325-8

Yancy CW, Jessup M, Bozkurt B, Masoudi FA, et al; ACCF/AHA Task Force Members. “2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.” J Am Coll Cardiol. 2013 Jun 5.

Anti-Aging Therapeutics Volume XV

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