Читать книгу Anti-Aging Therapeutics Volume XVI - A4M American Academy - Страница 23

If an anti-aging program is to be successful it needs to include therapies that will improve arterial health, enhance autophagy, and prevent premature senescence. Patients need to be encouraged to exercise every day. They need to eat a diet that is rich in antioxidants and spermidine, and which incorporates CR. They need to maintain their BMI between 20.0 and 24.9, and they need to endure that they remain sensitive to insulin. Finally, they need to avoid nicotine.

The problem with placing patients on programs that involve them doing a lot of exercise and making major changes to their diet is compliance. If they can’t see any real benefits in the short-term they are likely to slip back into old habits. However, there is a simple and inexpensive urine test that can be used to measure oxidative stress, which we now know hampers autophagy, causes premature senescence, and drives arterial disease. F2-isoprostane testing enables us to objectively measure oxidative stress. The great thing about this is it enables patients to directly see the impact of all their hard work. This helps to motivate them and works wonders with compliance; it is also useful for identifying patients who perhaps are not exercising as often as they say they are. In short, the F2-isoprostane test is a very useful addition to a comprehensive anti-aging program.