Читать книгу Project Management in Clinical Trials - Alexey Levashov - Страница 9

Timelines have major impact on cost, because there are a lot of parameters directly dependent on time. At the same time, normally timeline decrease or increase does not lead to proportionate decrease or increase in cost.

For example, if timelines are shortened by two times due to treatment and follow-up duration decrease, which is typical of premature study completion due to the lack of efficacy and/or safety concerns, the cost will not become twice smaller. The reason for this is that set-up and closure, which are much more labor intensive and costly, remain intact and they are more important cost-drivers for the study as a whole than treatment and follow-up.