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I am indebted to Professor Simon Shorvon who wrote the original chapter in Neurology A Queen Square Textbook Second Edition. Edited by Charles Clarke, Robin Howard, Martin Rossor & Simon Shorvon, Wiley Blackwell, 2016.

I am also most grateful to Dame Sally Davies, former Chief Medical of Health for England and to Dr Elizabeth Davies, Reader in Cancer & Public Health, King’s College, London who reviewed and commented on my text.