Читать книгу Structure and Function of the Bacterial Genome - Charles J. Dorman - Страница 31

DNA‐binding proteins play important roles in organising the structure of the folded chromosome, with some of these proteins having a chromosome‐domain‐specific binding pattern (Dame et al. 2011). The SeqA protein was introduced during the description of factors involved in the control of the initiation of chromosome replication (Section 1.3). SeqA accompanies the moving replication fork (Brendler et al. 2000; Onogi et al. 1999), resulting in a dynamic pattern of binding around the chromosome (Sánchez‐Romero et al. 2010; Waldminghaus and Skarstad 2010). This protein seems to be excluded from binding within the Ter macrodomain, possibly reflecting the absence from Ter of matches to the consensus sequence for SeqA high‐affinity binding sites (Sánchez‐Romero et al. 2010; Waldminghaus and Skarstad 2010). The SeqA protein can interact with the cell envelope as well as hemimethylated DNA (D'Alençon et al. 1999; Mika et al. 2015; Shakibai et al. 1998; Slater et al. 1995) so may it play a role in the positioning of Ori during cell division (Dame et al. 2011).