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Prologue An Exhumation

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In the early hours of 17 September 2008, a bizarre scene took place in the graveyard of St Mary’s Church, Sledmere, high up on the Yorkshire Wolds. In a corner of the cemetery hidden by yew trees were two tents illuminated by floodlights, from which there would occasionally emerge figures dressed in full biochemical warfare suits, their shapes creating eerie shadows on the outer walls of the church. But this was no science-fiction movie. It was an exhumation, of a man who had died nearly 100 years previously, and it was hoped that his remains might provide evidence that in the future could save the lives of billions.

The grave that was being opened up on that early autumn morning was that of Sir Mark Sykes, 6th Baronet of Sledmere, and MP for East Hull. He had passed away on 16 February 1919, aged thirty-nine, a victim of the Spanish flu, a particularly deadly strain of influenza that had swept across the world towards the end of the First World War, killing 10 per cent of all those it infected. At the time of his demise, Sykes was staying in Paris, where he had been attending the Peace Conference. Had he been a poor man he would have been buried at once nearby, the custom having been to bury victims of the flu as quickly as possible to avoid the further danger of spreading the virus by moving them. However, if a family could afford to pay for the body to be sealed in a lead coffin, a very expensive process, then it could be shipped home for burial, which is how Sykes came to lie in rest in a quiet corner of East Yorkshire rather than in a far-off Paris cemetery.

Though there have been many other strains of influenza in the intervening years, none have been as toxic as the Spanish flu, so called because Spain was the first country to report news of large numbers of fatalities. A Type-A virus classified as H1N1, and thought to have originated in poultry, it broke out in 1918, probably in America, and spread like wildfire partly owing to the movement of troops at the end of the war. Its symptoms were exceptionally severe, and it had an extremely high infection rate, which was the cause of the huge death toll. What made it exceptional, however, was that unlike most strains of influenza, which are normally deadly to the very young and the very old, more than half the people killed by H1N1 were young adults aged between twenty and forty. By the time any of the therapeutic measures employed gave a hint of being successful, the virus was on the wane and between 50 million and 100 million people had already died. It was a death toll that has haunted virologists ever since.

To this day, the great, unanswered question about H1N1 is how this dangerous strain of ‘avian flu’ made the leap to humans, one that has become even more urgent since the emergence in the 1990s of a yet more highly pathogenic virus, H5N1, first documented in Hong Kong in 1997. Using isolated viral fragments from H1N1 flu victims, of which there were only five examples known worldwide, mostly from bodies preserved in permafrost, scientists were able to reconstruct a key protein from the 1918 virus. Called haemagglutinin, it adopts a shape that allows it readily to latch on to human cells, and its discovery went a long way to helping virologists understand how such viruses adapt to new species. It struck one of them, Professor John Oxford, of Queen Mary University of London, that if modern methods of extracting DNA could derive so much information from frozen samples, then a great deal more could be extracted from soft tissue, such as might be found in a well-preserved body that had been sealed in a lead-lined coffin. He knew exactly the condition in which such a body might be found from photographs he had been shown of the freshly exhumed body of a woman who had been interred in a lead casket in the eighteenth century in a cemetery in Smithfield. ‘This lady was lying back in the lead coffin,’ he said, ‘with blue eyes. She was wrapped in silks, and had been in that coffin for two hundred years. She was perfectly preserved.’


Oxford knew that ‘We could take for example a big piece of lung, work on it, do the pathology and find out exactly how that person died, so in the next pandemic we would know to be especially careful about certain things.’1 Ian Cundall, a contact in the BBC, told him the story of Sir Mark Sykes, and he decided to contact the living relatives, who all gave their permission for the project to go ahead. This included moving the coffin of Sykes’s wife, who had died eleven years after him and had been buried in the same grave. After the Home Office and the Health and Safety Executive had been satisfied that the operation would involve absolutely no risk to the public, all that was left was for the local Bishop and Rural Dean to give their assent.

The exhumation team dug until they reached the remains of the coffin of Sykes’s wife, Edith, which, being made of wood, had disintegrated, leaving only the bones. These were carefully moved aside before the dig was continued, the utmost care being taken until one end of Sir Mark’s lead coffin was exposed. At first this looked to be in good condition, until it was noticed that there was a four-inch split in the lid. ‘That didn’t bode well,’ reflected Oxford. They pulled back the coffin’s lead covering, to find that, as Oxford had suspected when he saw the split, the body was not in the perfect condition they had so prayed for. The clothes had disintegrated and the remains were entirely skeletal. The team managed to recover some hair, however, which was important as that would possibly include the root and some skin, and, as usually happens, the lungs had collapsed onto the spinal cord, allowing the anatomist to remove some dark, hard tissue. Finally they extracted what might have been brain tissue from within the skull. With the exhumation at an end, prayers were recited, and then the team stood round the re-closed grave and sang ‘Roses of Picardy’, the song that soldiers used to sing on the way to the front. When the news of the exhumation finally reached the ears of the Press, there followed a rash of headlines such as ‘Dead Toff May Hold Bird Flu Clue’.

Though the samples removed from Sykes’s grave have revealed nothing so far, there is always hope that they may in the future. New advances in technology have allowed scientists to take DNA samples from dinosaurs that died thousands of years ago, and it is known that even in circumstances where it has been poorly preserved, a virus can leave a genetic footprint. So the chance exists that in the future a vaccine may be created that has its origins in tissue taken from the body of Mark Sykes, and which would protect the world from an H5N1 pandemic that could, with intercontinental travel as common as it is today, kill billions. If that were to happen it would be a great posthumous legacy for a man who has been reviled for what he achieved in his lifetime, namely the creation of what is known today as the Middle East through the Sykes–Picot Agreement. When he signed his name in 1916 to this piece of diplomacy, which has been since derided as ‘iniquitous’, ‘unjust’ and ‘nefarious’, he was only thirty-six years old.

The Man Who Created the Middle East: A Story of Empire, Conflict and the Sykes-Picot Agreement

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