Читать книгу Randomised Clinical Trials - David Machin - Страница 58

Although full details are not provided, there were unavoidable delays between randomisation and the commencement of radiotherapy (RT) in a trial conducted by the Medical Research Council Lung Cancer Working Party (1996). This resulted in 3/255 (1.2%) patients allocated 2‐fractions and 6/254 (2.4%) allocated 13‐fractions not receiving any radiotherapy at all. However, these are relatively small proportions, and so, the consequences of the dilution caused by these 9 (1.8%) patients not receiving any radiotherapy is likely to have little impact on the trial conclusions.