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Example 2.6 Immediate start of treatment– children with fever

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In a randomised controlled trial reported by Hay, Costelloe, Redmond, et al. (2008), the median time between randomisation and giving the first dose of study drug to children with fever was 8 minutes for paracetamol plus ibuprofen, 9 for paracetamol alone and 9 for the ibuprofen group. However, one suspects that this ideal state of affairs could not be replicated in too many situations.

Randomised Clinical Trials

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