Читать книгу Hemangioma. Questions & Answers - Дмитрий Романов - Страница 5

2.1. What is the cause for a hemanhioma to appear?

Infantile hemangioma appears at 6—10^th weeks of pregnancy, when damage of tissue (vessels) rudiment occurs. There are ca. 10 theories of infantile hemangioma development (fissural, neurological, traumatic, fetal, hypoxic etc). Among current theories we can call theory of circulating endothelial precursor cells, placental theory (placenta damage during pregnancy time) etc. Currently, however, there is no generally accepted and confirmed theory, which could reliably explain the appearance of infantile hemangiomas.

3D ultrasound reconstruction of the fetus at 10 weeks.

Possible causes of hemangiomas:

– amniocentesis, chorionic biopsy;

– mother’s age;

– mother’s level of education;

– multiple pregnancy;

– first labor;

– placenta previa;

– preeclampsia;

– placenta abnormalities (retroplacental hematoma, placental infarction, dilated vascular communications);

– placental hypoxia;

– if mother took erythropoietin and/or fertile drugs.

According to our and foreign studies, the cause for the infant hemangioma development is a viral disease of a pregnant woman (possibly, virus infection carrier state and/or contact with a viral patient) during the period from 6 to 10 weeks of pregnancy (first trimester). As a result of the virus penetration into the pregnant woman blood, the placental barrier gets damaged, which leads to the migration of placenta cells into the fetal skin. This theory is confirmed by the studies that have revealed that infant hemangioma cells are immunohistochemically identical to the placenta cells. Pathological cell masses occur in areas with a low blood flow and activate after the baby’s birth only (through hormonal release) and begin to form a pathological blood-vascular structure.