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Revascularization (+ISCHEMIA references 19,20)

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1 61. Hachamovitch R, Hayes SW, Friedman JD, et al. Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation 2003; 107: 2900–6.

2 62. Mancini GB, Hartigan PM, Shaw LJ, et al. Predicting outcomes in the COURAGE trial: coronary anatomy versus ischemia. JACC Cardiovasc Interv 2014; 7: 195–201. Only anatomic burden and EF are predictor of death and MI, not ischemic burden. PCI did not improve outcomes regardless of anatomic burden or ischemia.

3 63. Reynolds H. Relationships of ischemia severity and coronary artery disease extent with clinical outcomes in the ISCHEMIA trial. Presented at ACC. March 2020. Anatomic burden of disease is a strong predictor of death and cardiac outcomes, while ischemia was not an independent predictor of death and only marginally predicted MI. Mortality and MI were similar with invasive vs conservative strategy, regardless of the degree of ischemia severity or anatomic burden.

4 64. Mancini GB, Hartigan PM, Bates ER, et al. Angiographic disease progression and residual risk of cardiovascular events while on optimal medical therapy. Observations from the COURAGE Trial. Circ Cardiovasc Interv 2011; 4: 545–52.

5 65. Pijls NH, Fearon WF, Tonino PA, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME study. J Am Coll Cardiol 2010; 56: 177–84.

6 66. De Bruyne B, Pijls N, Kalesan B, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med 2012; 367: 991–1001.

7 67. Stone G.W., Maehara A., Lansky A.J., et al. PROSPECT Investigators A prospective natural-history study of coronary atherosclerosis. N Engl J Med 2011; 364: 226–235.

8 68. Yusuf S, Zucker D, Peduzzi P, et al. Effect of coronary artery bypass surgery on survival: Overview of 10-year results from randomized trials by the Coronary Artery Bypass Surgery Trialists Collaboration. Lancet 1994; 344: 563.

9 69. Velazquez EJ, Lee KL, Deja MA, et al.; STICH Investigators. Coronary-artery bypass surgery in patients with left ventricular dysfunction, N Engl J Med 2011; 364: 1607–16.

10 70. Velazquez EJ, Lee KL, Jones RH, et al. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy. N Engl J Med. 2016; 374(16):1511–1520.

Practical Cardiovascular Medicine

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