Читать книгу Practical Cardiovascular Medicine - Elias B. Hanna - Страница 77

1 98. Ariotti S, Adamo M, Costa F, et al; ZEUS Investigators. Is bare-metal stent implantation still justifiable in high bleeding risk patients undergoing percutaneous coronary intervention? a pre-specified analysis from the ZEUS trial. JACC Cardiovasc Interv. 2016; 9(5):426–436. In Zeus trial, patients with high bleeding risk received only 1 month of DAPT, whether randomized to BMS or Zotaralimus DES. Most patients had ACS at baseline (~50% MI). DES was associated with less MI and stent thrombosis than BMS.

2 99. Shah R, Rao SV, Latham SB, Kandzari DE, et al. Efficacy and safety of drug-eluting stents optimized for biocompatibility vs bare-metal stents with a single month of dual antiplatelet therapy: a meta-analysis. JAMA Cardiol 2018; 3:1050–1059. Meta-analysis of 3 trials, Zeus, Leaders free, and SENIOR, randomizing patients to BMS vs DES with only one month of DAPT; most patients had ACS at baseline. DES was superior to BMS, with less MI and stent thrombosis.

3 100. Hahn JY, Song YB, Oh JH, et al. Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention: The SMART-CHOICE Randomized Clinical Trial. JAMA 2019; 321: 2428-2437. Post-DES DAPT duration of 3 months (followed by clopidogrel monotherapy) was as safe as 12 months with less bleeding (27% MI at baseline).

4 101. Watanabe H, Domei T, Morimoto T, et al. Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial. JAMA 2019;321:2414-27. Post-DES DAPT duration of 1 month (followed by clopidogrel monotherapy) was as safe as 12 months, with less bleeding (25% MI at baseline).

5 102. Mehran R, Baber U, Sharma SK, et al. Ticagrelor With or Without Aspirin in High-Risk Patients After PCI. N Engl J Med 2019;381:2032-2042.

6 103. Hahn JY, Song YB, Oh JH, et al. 6-month versus 12-month or longer of dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome: a randomized, open label, non-inferiority trial (SMART DATE). Lancet 2018; 391: 1274-1284. In ACS, 6-month DAPT was associated with higher MI than 12-month, but less bleeding and similar mortality.

7 104. Airoldi F, Colombo A, Morici N. Incidence and predictors of drug-eluting stent thrombosis during and after discontinuation of thienopyridine treatment. Circulation 2007; 116: 745–54.

8 105. Schulz S, Schuster T, Mehilli J, et al. Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period. Eur Heart J 2009; 30: 2714–21.