Читать книгу The Wonders of Life: A Popular Study of Biological Philosophy - Ernst Haeckel - Страница 10

Table of Contents

Life and death—Individual death—Immortality of the unicellulars—Death of the protists and tissue-organisms—Causes of physiological death—Using up of the plasma—Regeneration—Biotonus—Perigenesis of the plastidules: memory of the biogens—Regeneration of protists and tissue-organisms—Senile debility—Disease—Necrobiosis—The lot of death—Providence—Chance and fate—Eternal life—Optimism and pessimism—Suicide and self-redemption—Redemption from evil—Medicine and philosophy—Maintenance of life—Spartan selection.

Nothing is constant but change! All existence is a perpetual flux of "being and becoming"! That is the broad lesson of the evolution of the world, taken as a whole or in its various parts. Substance alone is eternal and unchangeable, whether we call this all-embracing world-being Nature, or Cosmos, or God, or World-spirit. The law of substance teaches us that it reveals itself to us in an infinite variety of forms, but that its essential attributes, matter and energy, are constant. All individual forms of substance are doomed to destruction. That will be the fate of the sun and its encircling planets, and of the organisms that now people the earth—the fate of the bacterium and of man. Just as the existence of every organic individual had a beginning, it will also undeniably have an end. Life and death are irrevocably united. However, philosophers and biologists hold very different views as to the real causes of this destiny. Most of their opinions are at once out of court, because they have not a clear idea of the nature of life, and so can have no adequate idea of its termination—death.

The inquiry into the nature of organic life which we instituted in the second chapter has shown us that it is, in the ultimate analysis, a chemical process. The "miracle of life" is in essence nothing but the metabolism of the living matter, or of the plasm. Recent physiologists, especially Max Verworn and Max Kassowitz, have pointed out, in opposition to modern vitalism, that "life consists in a continuous alternation between the upbuild and the decay of the highly complicated chemical unities of the protoplasm. And if this conception is admitted, we may rightly say that we know what we mean by death. If death is the cessation of life, we must mean by that the cessation of the alternation between the upbuild and the dissolution of the molecules of protoplasm; and as each of the molecules of protoplasm must break up again shortly after its formation, we have in death to deal only with the definite cessation of reconstruction in the destroyed plasma-molecules. Hence a living thing is not finally dead—that is to say, absolutely incompetent to discharge any further vital function—until the whole of its plasma-molecules are destroyed." In the exhaustive justification with which Kassowitz follows up this definition in the fifteenth chapter of his General Biology, the natural causes of physiological death are fully described.

Among the numerous and contradictory views of recent biologists on the nature of death we find many errors and misunderstandings, due to a lack of clear distinction between the duration of the living matter in general and that of the individual life-form. This is particularly noticeable in the contradictory views which have been elicited by August Weismann's theory (1882) of the immortality of the unicellulars. I have shown in the eleventh chapter of the Riddle that it is untenable. But as the distinguished zoologist has again taken up his theory with energy in his instructive Lectures on the Theory of the Descent (1902), and has added to it erroneous observations on the nature of death, I am obliged to return to the point. Precisely because this interesting work gives most valuable support to the theory of evolution, and maintains Darwin's theory of selection and its consequences with great effect, I feel it is necessary to point out considerable weaknesses and dangerous errors in it. The chief of these is the important theory of the germ-plasm and the consequent opposition to the inheritance of acquired characteristics. Weismann deduces from this a radical distinction between the unicellular and the multicellular organisms. The latter alone are mortal, the former immortal; "between the unicellular and the multicellular lies the introduction of physiological—that is to say, normal—death." We must say, in opposition to this, that the physiological individuals (bionta) among the protista are just as limited in their duration as among the histona. But if the chief stress in the question is laid, not on the individuality of the living matter, but on the continuity of the metabolic life-movement through a series of generations, it is just as correct to affirm a partial immortality of the plasm for the multicellulars as for the unicellulars.

The immortality of the unicellulars, on which Weismann has laid so much stress, can only be sustained for a small part of the protists even in his own sense—namely, for those which simply propagate by cleavage, the chromacea and bacteria among the monera (chapter ix.), the diatomes and paulotomes among the protophyta, and a part of the infusoria and rhizopods among the protozoa. Strictly speaking, the individual life is destroyed when a cell splits into two daughter-cells. One might reply with Weismann that in this case the dividing unicellular organism lives on as a whole in its offspring, and that we have no corpse, no dead remains of the living matter, left behind. But that is not true of the majority of the protozoa. In the highly developed ciliata the chief nucleus is lost, and there must be from time to time a conjugation of two cells and a mutual fertilization of their secondary nuclei, before there can be any further multiplication by simple cleavage. However, in most of the sporozoa and rhizopoda, which generally propagate by spore formation, only one portion of the unicellular organism is used for this; the other portion dies, and forms a "corpse." In the large rhizopods (thalamophora and radiolaria) the spore-forming inner part, which lives on in the offspring, is smaller than the decaying outer portion, which becomes the corpse.

Weismann's view of the secondary "introduction of physiological death in the multicellulars" is just as untenable as his theory of the immortality of the unicellulars. According to this opinion, the death of the histona—both the metaphyta and metazoa—is a purposive outcome of adaptation, only introduced by selection when the multicellular organism has reached a certain stage of complexity of structure, which is incompatible with its original immortality. Natural selection would thus kill the immortal and preserve only the mortal; it would interfere with the multiplication of the immortals in the bloom of their years, and only use the mortal for rearing posterity. The curious conclusions which Weismann reached in developing this theory of death, and the striking contradictions to his own theory of the germ-plasm which he fell into, have been pointed out by Kassowitz in the forty-ninth chapter of his General Biology. In my opinion, this paradoxical theory of death has no more basis than the germ-plasm theory he has ingeniously connected with it. We may admire the subtlety and depth of the speculations with which Weismann has worked out his elaborate molecular theory. But the nearer we get to its foundations the less solid we find them. Moreover, not one of the many supporters of the theory of germ-plasm has been able to make profitable use of it in the twenty years since it was first published. On the other hand, it has had an evil influence in so far as it denied the inheriting of acquired characters, which I hold, with Lamarck and Darwin, to be one of the soundest and most indispensable supports of the theory of descent.

In discussing the question of the real causes of death, we confine our attention to normal or physiological death without considering the innumerable causes of accidental or pathological death, by illness, parasites, mishaps, etc. Normal death takes place in all organisms when the limit of the hereditary term of life is reached. This limit varies enormously in different classes of organisms. Many of the unicellular protophyta and protozoa live only a few hours, others several months or years; many one-year plants and lower animals live only a summer in our temperate climate, and only a few weeks or months in the arctic circle or on the snow-covered Alps. On the other hand, the larger vertebrates are not uncommonly a hundred years old, and many trees live for a thousand years. The normal span of life has been determined in all species in the course of their evolution by adaptation to special conditions, and has then been transmitted to offspring by heredity. In the latter, however, it is often subject to considerable modifications.

The organism has been compared, on the modern "machine theory" of life, to an artificially constructed mechanism, or an apparatus in which the human intelligence has put together various parts for the attainment of a certain end. This comparison is inapplicable to the lowest organisms, the monera, which are devoid of such a mechanical structure. In these primitive "organisms without organs" (chromacea and bacteria) the sole cause of life is the invisible chemical structure of the plasm and the metabolism effected by this. As soon as this ceases death takes place (cf. chapter ix.). In the case of all other organisms the comparison is useful in so far as the orderly co-operation of the various organs or parts accomplishes a certain task by the conversion of virtual into active force. But the great difference between the two is that in the case of the machine the regularity is due to the purposive and consciously acting will of man, whereas in the case of the organism it is produced by unconscious natural selection without any design. On the other hand, the two have another important feature in common in the limited span of life which is involved in their being used up. A locomotive, ship, telegraph, or piano, will last only a certain number of years. All their parts are worn out by long use, and, in spite of all repairing, become at last useless. So in the case of all organisms, the various parts are sooner or later worn out and rendered useless; this is equally true of the organella of the protist and the organs of the histon. It is true that the parts may be repaired or regenerated; but sooner or later they cease to be of service, and become the cause of death.

When we take the idea of regeneration, or the recuperation of parts that have been rendered useless, in the widest sense, we find it to be a universal vital function of the greatest importance. The whole metabolism of the living organism consists in the assimilation of plasm, or the replacing of the plasma-particles which are constantly used up by dissimilation (cf. chapter x.). Verworn has given the name of biogens to the hypothetical molecules of living matter—which I regard with Hering as endowed with memory, and (1875) have called plastidules. He says: "The biogens are the real vehicles of life. In their constant decay and reconstruction consists the process of life, which expresses itself in the great variety of vital phenomena." The relation of assimilation (the building-up of the biogens) to dissimilation (the decay of the biogens) may be expressed by a fraction to which the name biotonus is given A/D. It is of radical importance in the various phenomena of life. The variations in the size of this fraction are the cause of all change in the life-expression of every organism. When the biotone increases, and the metabolism quotient becomes more than one, we have growth; when, on the other hand, it falls below one, and the biotone decreases, we have atrophy, and finally death. New biogens are constructed in regeneration. In generation or reproduction groups of biogens (as germ-plasm) are released from the parent in consequence of redundant growth, and form the foundation of new individuals.

The phenomena of regeneration are extremely varied, and have of late years been made the subject of a good deal of comprehensive experiment, especially on the side of what is called "mechanical embryology." Many of these experimental embryologists have drawn far-reaching conclusions from their somewhat narrow experiments, and have partly urged them as objections to Darwinism. They imagine that they have disproved the theory of selection. Most of these efforts betray a notable lack of general physiological and morphological knowledge. As they also generally ignore the biogenetic law, and take no account of the fundamental correlation of embryology and stem history, we can hardly wonder that they reach the most absurd and contradictory conclusions. Many examples of this will be found in the Archiv für Entwickelungsmechanik. When, however, we make a comprehensive survey of the interesting field of regeneration processes, we discover a continuous series of development from the simplest repair of plasm in the unicellular protists to the sexual generation of the higher histona. The sperm-cells and ova of the latter are redundant growth-products, which have the power of regenerating the whole multicellular organism. But many of the higher histona have also the capacity to produce new individuals by regeneration from detached pieces of tissue, or even single cells. In the peculiar mode of metabolism and growth which accompanies these processes of regeneration, the memory of the plastidule, or the unconscious retentive power of the biogens, plays the chief part (cf. my Perigenesis of the Plastidule, 1875). In the most primitive kinds of the unicellular protists we find the phenomena of death and regeneration in the simplest form. When an unnucleated moneron (a chromaceum or bacterium) divides into two equal halves, the existence of the dividing individual comes to an end. Each half regenerates itself in the simplest conceivable way by assimilation and growth, until it, in turn, reaches the size of the parent organism. In the nucleated cells of most of the protophyta and protozoa it is more complicated, as the nucleus becomes active as the central organ and regulator of the metabolism. If an infusorium is cut into two pieces, only one of which contains the nucleus, this one alone grows into a complete nucleated cell; the unnucleated portion dies, being unable to regenerate itself.

In the multicellular body of the tissue-forming organisms we must distinguish between the partial death of the various cells and the total death of the whole organism, or cell-state, which they make up. In many of the lower tissue-plants and tissue-animals the communal link is very loose and the centralization slight. Odd cells or groups of cells may be set loose, without any danger to the life of the whole histon, and grow into new individuals. In many of the algæ and liverworts (even in the bryophyllum, closely related to the stone-crop, or sedum)—as well as in the common fresh-water polyp, hydra, and other polyps—every bit that is cut off is capable of growing into a complete individual. But the higher the organization is developed and the closer the correlation of the parts and their co-operation in the life of the centralized stock or person, the slighter we find the regenerative faculty of the several organs. Even then, however, many used-up cells may be removed and replaced by regenerated new cells. In our own human organism, as in that of the higher animals, thousands of cells die every day, and are replaced by new cells of the same kind, as, for instance, epidermic cells at the surface of the skin, the cells of the salivary glands or the mucous lining of the stomach, the blood-cells, and so on. On the other hand, there are tissues that have little or nothing of this repairing power, such as many of the nerve-cells, sense-cells, muscle-cells, etc. In these cases a number of constant cell-individuals remain with their nucleus throughout life, although a used-up portion of their cell-body may be replaced by regeneration from the cytoplasm. Thus our human body, like that of all the higher animals and plants, is a "cell-state" in another sense. Every day, nay, every hour, thousands of its citizens, the tissue-cells, pass away, and are replaced by others that have arisen by cleavage of similar cells. Nevertheless, this uninterrupted change of our personality is never complete or general. There is always a solid groundwork of conservative cells, the descendants of which secure the further regeneration.

Most organisms meet their death through external or accidental causes—lack of sufficient food, isolation from their necessary environment, parasites and other enemies, accidents and disease. The few individuals who escape these accidental causes of death find the end of life in old age or senility, by the gradual decay of the organs and dwindling of their functions. The cause of this senility and the ensuing natural death is determined for each species of organisms by the specific nature of their plasm. As Kassowitz has lately pointed out, the senility of individuals consists in the inevitable increase in the decay of protoplasm and the metaplastic parts of the body which this produces. Each metaplasm in the body favors the inactive break-up of protoplasm, and so also the formation of new metaplasms. The death of the cells follows, because the chemical energy of the plasm gradually falls off from a certain height, the acme, of life. The plasm loses more and more the power to replace by regeneration the losses it sustains by the vital functions. As, in the mental life, the receptivity of the brain and the acuteness of the senses gradually decay, so the muscles lose their energy, the bones become fragile, the skin dry and withered, the elasticity and endurance of the movements decrease. All these normal processes of senile decay are caused by chemical changes in the plasm, in which dissimilation gains constantly on assimilation. In the end they inevitably lead to normal death.