Читать книгу Periodontics - Fernando Suarez - Страница 71

The degree that periodontitis is influenced by genetics has been investigated in a number of studies. The role of genetics appears to be more significant in specific categories of periodontitis with rapid progression (previously known as aggressive periodontitis). The mode of transmission, however, remains unclear. The majority of the studies point toward autosomal dominant mode,⁴² while others report X-linked or autosomal recessive.⁴³

For the majority of the rest of the phenotypic expressions of periodontitis (chronic periodontitis), evidence from cross-sectional studies in twins suggest that genetics (heritability) are responsible for up to 50% of the manifestation of the disease.⁴⁴ Furthermore, a specific genotype of interleukin 1 β (IL-1β) has been shown to be associated with increased disease severity^45,46 and a 2.7-fold increase in risk of tooth loss.²⁹