Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 127

Phase I studies can be used to look at specific safety issues in drug development. For example, based on pharmacology or toxicology results, a drug may be thought to have potential to cause QT interval prolongation on the ECG which may predispose to cardiac arrhythmias. A simple Phase I study using an escalating dose of drug with ECG recording can show whether there is any relationship between concentration of drug in the plasma and QT interval.