Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 155

When drug treatment is indicated, it is mandatory that the most appropriate agent is given in the correct dose and in a regimen that results in optimum treatment with minimum adverse effects. Selection of the best drug requires consideration of factors that relate not only to the range of drugs available, but also to both the patient and the condition being treated. Age and disease may influence kinetics and dynamics to a significant degree and should be reflected in the choice of agent. Choosing the wrong drug (such as diclofenac over paracetamol for mild headache in a patient with renal impairment) may aggravate existing medical conditions. As discussed later in this chapter, concomitant therapy for co‐morbid conditions may interact with any new prescription, with occasionally catastrophic results.