Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 163

These tend to involve the administration of two drugs with similar effects. Such interactions may involve two agents acting at one receptor (attenuation of salbutamol's bronchodilatory effect by non‐specific beta‐blockers) or through a less specific effect upon particular tissues (potentiation of the sedative effect of benzodiazepines by alcohol). Pharmacodynamic interactions at one receptor may have therapeutic use, such as the reversal of opiate toxicity by naloxone. The clinical effects are largely predictable and can be prevented by thoughtful prescribing.