Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 32

Enzyme induction produces clinical changes over days or weeks, but the effects of enzyme inhibition are usually observed immediately. In most circumstances, these changes are manifest as:

 Therapeutic failure resulting from induction

 Adverse effects resulting from inhibition

Clinical relevance occurs when drug therapy needs to be altered to avoid the consequences of the drug interaction and this is most common and most serious in compounds that have a narrow therapeutic index.