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The Global FAST approach is imperative for PCE cases, especially in dogs in which nonhemoabdomen ascites (and echo negative for a mass) has been shown to carry a much more favorable prognosis, with median survival times much different at 605 days versus 45 days (Stafford Johnson et al. 2004). The presence of a mass (echo‐positive versus echo‐negative) also has great influence on the prognosis, with similar large differences in survival between those without echo‐detected masses and those with – 1068 days versus 26 days (Stafford Johnson et al. 2004). Furthermore, in the large study done by MacDonald and colleagues, of those with masses, no matter the type of tumor, metastasis was high (~50–66%) and thoracic radiography only detected ~33% of lung metastasis (MacDonald et al. 2009). Global FAST with its target organ approach has the potential to detect intraabdominal metastasis as well as pulmonary, and Vet BLUE has been shown to perform better than thoracic radiography in a pilot study (Kulhavy and Lisciandro 2015) (see Chapter 36).