Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 158

Hematopoietic stem cell therapy takes three forms, classified according to the donor sources for transplant:

1 Allogeneic transplantation—the source is from another person (i.e., a related or unrelated donor according to the degree of HLA matching between the donor and the patient). A well-matched transplant decreases the risks of morbidity and mortality.

2 Autologous transplantation—the source is the patient and is usually used as a rescue therapy, to reconstitute the patient’s hematopoietic system after aggressive chemotherapy.

3 Syngeneic transplantation—the source is an identical twin, although the former two have taken precedence over this form of treatment in the recent years.

HSCs were first used for the treatment of leukemia and lymphomas, for inherited blood cell disorders and inborn errors of metabolism, autoimmune disorders, and in stem cell rescue following chemotherapy; some of the major indications for stem cell transplant in adults are listed in Table 1, and some of these pathologies will be discussed further on.

Table 1