Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 162

In the late 1990s, stem cells were used in the treatment of patients with severe autoimmune diseases. Both myeloablative and non-myeloablative regimens have been tried prior to hematopoietic stem cell transplant (HSCT).

Patients with systemic sclerosis treated by autologous HSCT showed signs of better skin tightness and joint flexibility, along with some patients who exhibited a reversal of pulmonary alvelolitis.

Promising results have also been shown in patients with Crohn’s disease, where the immune system attacks microbial antigens leading to intestinal inflammation; autologous HSCT has shown to improve the condition considerably and improve quality of life.

Other autoimmune conditions that have been successfully treated by HSCT include systemic lupus erythematous (SLE) and rheumatoid arthritis.