Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 224

Lineage tracing or tracking is a more recent technique that was created with the ability to genetically mark specific cells in the breast with molecular signatures known as reporters. Once marked, these parent cells would be able to transmit the reporter to all the daughter cells that arise through cell proliferation and differentiation. Thus the lineage of individual cells can be tracked through this method, making it easy to identify multipotent stem cells in the breast. Since both the cell type and the timing at which the reporter is activated can be controlled, lineage tracing can identify stem cells with more accuracy. Some of the drawbacks of this technique include technical difficulty in labeling specific cell populations and the off-target expression of the reporter molecule.