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Phase III studies provide the pharmaceutical company and the FDA with a more thorough understanding of the effectiveness of the drug/treatment, benefits, and the range of possible adverse reactions. These studies involve several hundred to several thousand patients and can last several years. Once Phase III is complete, a pharmaceutical company can request FDA approval for marketing the drug. Some of the recent phase III trials in the US are listed below.

 A Clinical Evaluation of the Safety of Baclofen Er Capsules (Grs) When Administered Once Daily to Subjects With Spasticity Due to Multiple Sclerosis. A Randomized Trial of Two Formal Group Programs for Multiple Sclerosis: this trial involves behavioral therapy and techniques to help relieve fatigue and other symptoms associated with MS.

 Vitamin D in Multiple Sclerosis: low vitamin D levels are known to be associated with increased risk of developing MS, and patients with MS who have lower vitamin D levels are at increased risk of having attacks. However, it is not known if giving supplemental vitamin D to those with MS reduces the risk of attacks, and some research suggests that vitamin D could even be harmful to people with MS.

 Oral Cladribine in Early Multiple Sclerosis (MS).

 Combination Therapy in Patients with Relapsing-Remitting Multiple Sclerosis (MS).

 Duloxetine for Multiple Sclerosis Pain. A Study of Ocrelizumab in Patients with Primary Progressive Multiple Sclerosis