Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 83

Early onset (<5%): Symptoms appear before age 60 and are less common than late onset. It progresses and worsens quickly. Early onset disease can be hereditary; mutations in the genes for amyloid precursor protein, presenelin-1, and presenelin-2 have been identified.

Late onset: The most common type. Symptoms occur after 60. Although hereditary associations have been identified, the role of genes is less clear. Converging environmental and genetic risk factors appear to contribute in the development of the disease. Advancing age, family history, ApoE (apolipoprotein E) genotype, obesity, insulin resistance, vascular factors, Down syndrome, and traumatic brain injury are the most common etiologies. Newer epidemiologic studies have associated aluminum and previous depression with AD development.