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1.3.1 Description

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During this stage, the enamel organ resembles a bell. It is during this stage that the tooth crown will undertake its final shape (morphodifferentiation) and ameloblasts along with odontoblasts are histodifferentiated. The region where the outer and inner enamel epithelial cells meet at the border of enamel organ is called the cervical loop. In between the stellate reticulum and the inner enamel epithelial cells, some of the cell population differentiates and forms a new layer of cells called stratum intermedium. The cells of the inner enamel epithelium and stratum intermedium work collaboratively to form the enamel tissue. The enamel organ during the early bell stage clearly shows its four diverse layers: outer enamel epithelium, inner enamel epithelium, stellate reticulum, and stratum intermedium. During this stage, the enamel organ loses its contact with the oral epithelium as the dental lamina is broken down. This connection is restored during the process of tooth eruption. The remnants of dental lamina are called epithelial rest of Serres. In the early bell stage, the enamel knot disappears and the enamel cord appears between the stratum intermedium and stellate reticulum.

An Illustrated Guide to Oral Histology

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