Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 32

A high content in histiocytes is present in some PTCL entities. For example in the lymphohistiocytic variant of ALCL ALK‐positive, which occurs exclusively in children and young adults, the gene expression signature is largely contributed by the histiocytic component and, in comparison to the classical disease the patients have a more disseminated disease with tendency to a leukemic picture and a worse prognosis with a high risk of failure [77]. Conversely, the lymphoepithelioid variant of PTCL, NOS tends to be associated with an overall better prognosis than other PTCL‐NOS [78, 79]. In PTCL, NOS rich in histiocytes, the molecular signature related to inflammatory response (chemokines, cathepsins, major histocompatibility complex (MHC) molecules, genes involved in the interferon response pathway) and to the monocyte–macrophage background appears to be inversely related to a proliferation signature and associated with an adverse prognosis [80, 81].